Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Isl2  insulin related protein 2 (islet 2)   (Synonyms: 3110001N10Rik, islet 2, islet-2)
Results	Reference
1	J:184160 Abdo H, Li L, Lallemend F, Bachy I, Xu XJ, Rice FL, Ernfors P, Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci. 2011 Nov;34(10):1529-41
1	J:237454 Abdulhaleem FA, Song X, Kawano R, Uezono N, Ito A, Ahmed G, Hossain M, Nakashima K, Tanaka H, Ohta K, Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord. Dev Neurobiol. 2015 May;75(5):494-504
1	J:155074 Agalliu D, Takada S, Agalliu I, McMahon AP, Jessell TM, Motor neurons with axial muscle projections specified by Wnt4/5 signaling. Neuron. 2009 Mar 12;61(5):708-20
1	J:207519 Anderegg A, Lin HP, Chen JA, Caronia-Brown G, Cherepanova N, Yun B, Joksimovic M, Rock J, Harfe BD, Johnson R, Awatramani R, An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS Genet. 2013 Dec;9(12):e1003973
1	J:119656 Andrieu D, Meziane H, Marly F, Angelats C, Fernandez PA, Muscatelli F, Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. BMC Dev Biol. 2006;6:56
1	J:57340 Arber S, Han B, Mendelsohn M, Smith M, Jessell TM, Sockanathan S, Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron. 1999 Aug;23(4):659-74
1	J:78232 Arber S, Ladle DR, Lin JH, Frank E, Jessell TM, ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 2000 May 26;101(5):485-98
1	J:98179 Caubit X, Tiveron MC, Cremer H, Fasano L, Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain. J Comp Neurol. 2005 May 23;486(1):76-88
1	J:190166 Chen JA, Wichterle H, Apoptosis of limb innervating motor neurons and erosion of motor pool identity upon lineage specific dicer inactivation. Front Neurosci. 2012;6:69
1	J:268047 Cheng I, Jin L, Rose LC, Deppmann CD, Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system. Dev Neurobiol. 2018 Jul;78(7):701-717
1*	J:111162 Choe A, Phun HQ, Tieu DD, Hu YH, Carpenter EM, Expression patterns of Hox10 paralogous genes during lumbar spinal cord development. Gene Expr Patterns. 2006 Oct;6(7):730-7
1	J:166770 Coppola E, d'Autreaux F, Rijli FM, Brunet JF, Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development. 2010 Dec;137(24):4211-20
1	J:157532 Coppola E, Rallu M, Richard J, Dufour S, Riethmacher D, Guillemot F, Goridis C, Brunet JF, Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2066-71
1	J:180432 D'Autreaux F, Coppola E, Hirsch MR, Birchmeier C, Brunet JF, Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20018-23
1	J:139297 Dasen JS, De Camilli A, Wang B, Tucker PW, Jessell TM, Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1. Cell. 2008 Jul 25;134(2):304-16
1	J:132705 De Marco Garcia NV, Jessell TM, Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity. Neuron. 2008 Jan 24;57(2):217-31
1	J:278229 Dewitz C, Duan X, Zampieri N, Organization of motor pools depends on the combined function of N-cadherin and type II cadherins. Development. 2019 Jul 10;146(13):dev180422
1	J:271772 Dewitz C, Pimpinella S, Hackel P, Akalin A, Jessell TM, Zampieri N, Nuclear Organization in the Spinal Cord Depends on Motor Neuron Lamination Orchestrated by Catenin and Afadin Function. Cell Rep. 2018 Feb 13;22(7):1681-1694
1*	J:40032 Dou C, Ye X, Stewart C, Lai E, Li SC, TWH regulates the development of subsets of spinal cord neurons. Neuron. 1997 Apr;18(4):539-51
1	J:262472 Edmond M, Hanley O, Philippidou P, Topoisomerase IIbeta Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs. eNeuro. 2017 Nov-Dec;4(6):ENEURO.0404-17.2017
1*	J:70423 Eggenschwiler JT, Espinoza E, Anderson KV, Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature. 2001 Jul 12;412(6843):194-8
1	J:249229 Espinosa-Medina I, Outin E, Picard CA, Chettouh Z, Dymecki S, Consalez GG, Coppola E, Brunet JF, Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors. Science. 2014 Jul 4;345(6192):87-90
1	J:237201 Espinosa-Medina I, Saha O, Boismoreau F, Chettouh Z, Rossi F, Richardson WD, Brunet JF, The sacral autonomic outflow is sympathetic. Science. 2016 Nov 18;354(6314):893-897
1	J:312043 Galdo M, Gregonis J, Fiore CS, Compagnone NA, Dehydroepiandrosterone biosynthesis, role, and mechanism of action in the developing neural tube. Front Endocrinol (Lausanne). 2012;3:16
1*	J:65601 Garel S, Garcia-Dominguez M, Charnay P, Control of the migratory pathway of facial branchiomotor neurones. Development. 2000 Dec;127(24):5297-307
1*	J:227617 Garrett AM, Jucius TJ, Sigaud LP, Tang FL, Xiong WC, Ackerman SL, Burgess RW, Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. Front Mol Neurosci. 2016;9:3
1	J:98888 Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF, Generation and characterization of Rgs4 mutant mice. Mol Cell Biol. 2005 May;25(10):4221-8
1*	J:148194 Han DY, Kobayashi M, Nakano M, Atobe Y, Kadota T, Funakoshi K, Differential Islet-1 expression among lumbosacral spinal motor neurons in prenatal mouse. Brain Res. 2009 Apr 10;1265:30-6
1	J:160945 Haupt C, Kloos K, Faus-Kessler T, Huber AB, Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns. Eur J Neurosci. 2010 Apr 1;31(7):1164-72
1*	J:171311 Haupt C, Langhoff J, Huber AB, Adenylate Cyclase 1 modulates peripheral nerve branching patterns. Mol Cell Neurosci. 2010 Dec;45(4):439-48
1	J:345795 Hsu HC, Hsu SP, Hsu FY, Chang M, Chen JA, LncRNA Litchi is a regulator for harmonizing maturity and resilient functionality in spinal motor neurons. iScience. 2024 Mar 15;27(3):109207
1	J:215576 Itoh T, Horiuchi M, Ikeda RH Jr, Xu J, Bannerman P, Pleasure D, Penninger JM, Tournier C, Itoh A, ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J Neurosci. 2014 Aug 6;34(32):10729-42
1	J:112635 Ji SJ, Zhuang B, Falco C, Schneider A, Schuster-Gossler K, Gossler A, Sockanathan S, Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neurons. Dev Biol. 2006 Sep 1;297(1):249-61
1	J:166088 Jung H, Lacombe J, Mazzoni EO, Liem KF Jr, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS, Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron. 2010 Sep 9;67(5):781-96
1	J:102289 Kablar B, Belliveau AC, Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neurons. Dev Dyn. 2005 Nov;234(3):659-69
1*	J:54064 Kablar B, Rudnicki MA, Development in the absence of skeletal muscle results in the sequential ablation of motor neurons from the spinal cord to the brain. Dev Biol. 1999 Apr 1;208(1):93-109
1*	J:32806 Keller-Peck CR, Mullen RJ, Patterns of neuronal differentiation in neural tube mutant mice: curly tail and Pax3 splotch-delayed. J Comp Neurol. 1996 May 13;368(4):516-26
1	J:177794 Kobayashi M, Nakano M, Atobe Y, Kadota T, Funakoshi K, Islet-1 expression in thoracic spinal motor neurons in prenatal mouse. Int J Dev Neurosci. 2011 Nov;29(7):749-56
1	J:256120 Kuwajima T, Soares CA, Sitko AA, Lefebvre V, Mason C, SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System. Neuron. 2017 Mar 8;93(5):1110-1125.e5
1	J:201695 Lilley BN, Pan YA, Sanes JR, SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals. Neuron. 2013 Jul 10;79(1):39-53
1	J:239790 Marcos S, Gonzalez-Lazaro M, Beccari L, Carramolino L, Martin-Bermejo MJ, Amarie O, Mateos-San Martin D, Torroja C, Bogdanovic O, Doohan R, Puk O, Hrabe de Angelis M, Graw J, Gomez-Skarmeta JL, Casares F, Torres M, Bovolenta P, Meis1 coordinates a network of genes implicated in eye development and microphthalmia. Development. 2015 Sep 01;142(17):3009-20
1	J:296800 Munezane H, Oizumi H, Wakabayashi T, Nishio S, Hirasawa T, Sato T, Harada A, Yoshida T, Eguchi T, Yamanashi Y, Hashimoto T, Iwatsubo T, Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder. Cell Rep. 2019 Dec 24;29(13):4362-4376.e6
1	J:213589 Ono K, Clavairoly A, Nomura T, Gotoh H, Uno A, Armant O, Takebayashi H, Zhang Q, Shimamura K, Itohara S, Parras CM, Ikenaka K, Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2. Development. 2014 May;141(10):2075-84
1	J:39370 Ozaki S, Snider WD, Initial trajectories of sensory axons toward laminar targets in the developing mouse spinal cord. J Comp Neurol. 1997 Apr 7;380(2):215-29
1	J:305247 Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C, Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 2021 Apr;24(4):478-488
1	J:197494 Philippidou P, Walsh CM, Aubin J, Jeannotte L, Dasen JS, Sustained Hox5 gene activity is required for respiratory motor neuron development. Nat Neurosci. 2012 Dec;15(12):1636-44
1	J:250766 Poliak S, Morales D, Croteau LP, Krawchuk D, Palmesino E, Morton S, Cloutier JF, Charron F, Dalva MB, Ackerman SL, Kao TJ, Kania A, Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons. Elife. 2015 Dec 3;4:e10841
1	J:231738 Reed-Geaghan EG, Wright MC, See LA, Adelman PC, Lee KH, Koerber HR, Maricich SM, Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes. J Neurosci. 2016 Apr 13;36(15):4362-76
1	J:178550 Sabharwal P, Lee C, Park S, Rao M, Sockanathan S, GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron. 2011 Sep 22;71(6):1058-70
1	J:51420 Sharma K, Sheng HZ, Lettieri K, Li H, Karavanov A, Potter S, Westphal H, Pfaff SL, LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell. 1998 Dec 11;95(6):817-28
1	J:304680 Skarlatou S, Herent C, Toscano E, Mendes CS, Bouvier J, Zampieri N, Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection. Cell Rep. 2020 Jun 9;31(10):107741
1	J:287691 Suter TACS, Blagburn SV, Fisher SE, Anderson-Keightly HM, D'Elia KP, Jaworski A, TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation. Cell Rep. 2020 Jan 28;30(4):1164-1177.e7
1	J:89755 Thaler JP, Koo SJ, Kania A, Lettieri K, Andrews S, Cox C, Jessell TM, Pfaff SL, A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron. 2004 Feb 5;41(3):337-50
1*	J:45780 Tiret L, Le Mouellic H, Maury M, Brulet P, Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice. Development. 1998 Jan;125(2):279-91
1*	J:34768 Tremblay P, Pituello F, Gruss P, Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice. Development. 1996 Aug;122(8):2555-67
1	J:290264 Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L, Zampieri N, Landmesser LT, Philippidou P, Phrenic-specific transcriptional programs shape respiratory motor output. Elife. 2020 Jan 16;9:e52859
1	J:82071 Vermeren M, Maro GS, Bron R, McGonnell IM, Charnay P, Topilko P, Cohen J, Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points. Neuron. 2003 Feb 6;37(3):403-15
1	J:255944 Wang Q, Marcucci F, Cerullo I, Mason C, Ipsilateral and Contralateral Retinal Ganglion Cells Express Distinct Genes during Decussation at the Optic Chiasm. eNeuro. 2016 Nov-Dec;3(6):ENEURO.0169-16.2016
1	J:181639 Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C, The transcription factor c-Maf controls touch receptor development and function. Science. 2012 Mar 16;335(6074):1373-6
1*	J:224892 Yan Y, Wladyka C, Fujii J, Sockanathan S, Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006
1	J:194893 Yu K, McGlynn S, Matise MP, Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development. 2013 Apr;140(7):1594-604
1	J:226697 Yung AR, Nishitani AM, Goodrich LV, Phenotypic analysis of mice completely lacking netrin 1. Development. 2015 Nov 1;142(21):3686-91